The field of organic solar cells (OSCs) continues to grow rapidly as new non-fullerene small molecule acceptors are created to boost device efficiencies above 13% and with 15% in sight. The commercialization of nonfullerene OSCs relies critically on the response and lifetime under typical operating conditions (for instance, temperature, humidity) and the ability of scale-up fabrication in the cheapest and most benign way possible. Realizing high efficiency in printed nonfullerene OSCs via scalable materials and less toxic solvents remains a grand challenge, a challenge that is now timely to address as OSC efficiency in research devices has improved so much.